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If i understand it is not serum but bio available and free testosterone that are more important. I am also confused about the 2nd stage to testosterone which is an esterified testosterone. Is this esterified testosterone something that is not a natural form of testosterone? If not. I understand some doctors say testosterone is esterified testosterone. Can any advice be given here? Edit: I am looking for what I call a bioavailable testosterone which is a testosterone that is free of free-methyl or otherwise bio-available. Is this something that is actually a natural form of testosterone or is it a synthetic form? Is there any other type of bioavailable testosterone that I am not aware of (or can I ask)? Edit 2: I have found a lot of info concerning the "natural" form of testosterone. The problem with the natural form is it could be a product of a "laboratory" test and that "natural" testosterone could be a synthetic variation. What tests that test the natural form of testosterone are available? Edit 3: One of my friends mentioned this article in which Dr. Dowsett goes on to advise the patients with low T to use a pill like Depo for T3 and then take a small amount of "natural" T in the form of T4 (or any other vitamin) and if one does not have high levels of vitamin B12 or B6 (because their vitamin B12 level needs to be at "normal") then one can take Depo (usually 30-60 micrograms). Thanks all and please help me understand this and what a bioavailable testosterone does. EDIT 4: Hi, I am just curious if the T4 (methylenetetrahydrofolate) is biologically and chemically different than the T3 (methylenetetrahydrofolate)? I am not sure how this differs, but it's interesting. Thanks in advance! I don't know, but I like your question. It does seem really intriguing. Is there a difference between the T3 and the T4? Similar articles: